Comparison of density and morphology of neuroblasts in the dentate gyrus among variously aged dogs, German shepherds

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Abstract

Neural progenitor cells in the dentate subgranular zone (SGZ) produce new cells all through life via proliferation. We observed differences in neuroblasts using doublecortin (DCX, a marker of neuronal differentiation) in the SGZ in variously aged dogs (German shepherds). In the 1-year-old group, DCX-immunoreactive (+) cells were abundantly observed in the SGZ: These cells had processes extending into the molecular layer. In the 3-year-old group, DCX+ cells were decreased by 53.0% compared to that in the 1-year-old group, and DCX+ processes were also markedly decreased. In the 6 and 8-year-old groups, DCX+ cells were decreased by 34.3% and 62.9% vs. the pre-aged group. In the 8-year-old group, DCX+ cells were decreased by 86.4% compared to that in the 1-year-old group. In the 12-year-old group, DCX+ cells and processes were nearly disappeared. This suggests that DCX+ cells processes significantly decreased at 3 years in the SGZ of the German shepherd.

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Hwang, I. K., Yoo, K. Y., Park, O. K., Choi, J. H., Lee, C. H., & Won, M. H. (2009). Comparison of density and morphology of neuroblasts in the dentate gyrus among variously aged dogs, German shepherds. Journal of Veterinary Medical Science, 71(2), 211–215. https://doi.org/10.1292/jvms.71.211

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