Treatment of mice with heat-killed Propionibacterium (P.) acnes conferred transient protection against Toxoplasma infection. To investigate the mechanism of this nonspecific resistance, the production of gamma interferon (IFN-γ) by P. acnes-injected mice was evaluated in comparison with that by noninjected controls upon infection with Toxoplasma. Mice pretreated with this bacterium produced significantly more IFN-γ than that produced by control mice up to 24 hr of infection. A single injection of anti-IFN-γ MAb on day 0 but not later than day 3 of infection resulted in a total abrogation of the resistance conferred by P. acnes. Likewise, daily injection of cyclosporin A (Cs-A), a potent inhibitor of T cell function, during the first 3 days of Toxoplasma infection severely exacerbated the infection, in accordance with a marked suppression of the early IFN-γ production. In contrast, the administration of Cs-A for 3 consecutive days starting at day 4 had no significant consequence on P. acnes-induced anti-toxoplasma resistance, while it reduced greatly the ability of P. acnes-injected mice to produce IFN-γ in the later phase of infection. Moreover, no significant increase in mortality and suppression of IFN-γ production was noted in mice receiving anti-asialo GM1 antibody. These results suggest that the early IFN-γ production by T cells is an essential event for the establishment of P. acnes-induced anti-toxoplasma resistance in mice. © 1994, JAPANESE SOCIETY OF VETERINARY SCIENCE. All rights reserved.
CITATION STYLE
Nakane, A., Shimoi, A., Kanda, H., & Goto, H. (1994). Importance of Early Gamma Interferon Production in Propionibacterium acnes-Induced Resistance to Toxoplasma gondii Infection in Mice. Journal of Veterinary Medical Science, 56(2), 293–297. https://doi.org/10.1292/jvms.56.293
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