Intoxicación aguda por cocaína. A propósito de un caso

Abstract

Cocaine is a drug with distribution and consumption throughout the world. Its consumption extended mainly in the decades 1980-1990. The drugs produces cardiovascular effects following chronic administration and overdose, due to their potent vasoconstrictor effect secondary to the increase of synaptic concentrations of the monamine neurotransmitter dopamine, norepinphrine, and serotonin by binding to transporter proteins and blocking reuptake. Renal insufficiency due to rhabdomyolysis, and cardiovascular dysfunction have been reported following cocaine abuse, and may be fatal. We report a patient who developed renal insufficincy due to rhabdomyolysis and a cardiovascular disorder associated with cocaine abuse. We reviewew the disorders induced by cocaine abuse and their treatment. Copyright © 2006 Aran Ediciones, s.l.