Orchestrating Binding Interactions and the Emergence of Avidity Driven Therapeutics

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Abstract

Multiple carbohydrate ligands are arranged within a single therapeutic agent to achieve significant increases in apparent binding affinity or “avidity” for a target lectin receptor.

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Kapcan, E., Lake, B. P. M., & Rullo, A. F. (2023). Orchestrating Binding Interactions and the Emergence of Avidity Driven Therapeutics. ACS Central Science, 9(4), 586–589. https://doi.org/10.1021/acscentsci.3c00242

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