Efficacy and safety of entrectinib in patients with NTRK fusion-positive (NTRK-fp) Tumors: Pooled analysis of STARTRK-2, STARTRK-1 and ALKA-372-001

  • Demetri G
  • Paz-Ares L
  • Farago A
  • et al.
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Abstract

Conclusions: In this multicenter, pooled analysis of global clinical trials, entrectinib was well tolerated overall and induced clinically meaningful, durable systemic responses in pts with NTRK-fp solid tumors, type agnostic, with and without CNS disease.Clinical trial identification: EudraCT: 2012-000148-88; NCT02097810; NCT02568267.Legal entity responsible for the study: F. Hoffmann-La Roche.

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Demetri, G. D., Paz-Ares, L., Farago, A. F., Liu, S. V., Chawla, S. P., Tosi, D., … Doebele, R. C. (2018). Efficacy and safety of entrectinib in patients with NTRK fusion-positive (NTRK-fp) Tumors: Pooled analysis of STARTRK-2, STARTRK-1 and ALKA-372-001. Annals of Oncology, 29, viii713. https://doi.org/10.1093/annonc/mdy424.017

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