LEPR gene Gln223Arg polymorphism and type 2 diabetes mellitus: A meta-analysis of 3,367 subjects

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Background: The Leptin receptor (LEPR) Gln223Arg gene polymorphism has been associated with an increased susceptibility to Type 2 diabetes mellitus (T2DM). Results from various studies, however, are inconsistent. Objective and methods: To better elucidate the association of LEPR Gln223Arg gene polymorphism with T2DM in the Chinese population, a meta-analysis of 3,367 subjects from seven independent studies was performed. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CI) were evaluated by the fixed-effects model. Results: A significant relationship between LEPR Gln223Arg gene polymorphism and T2DM in the Chinese population was found under allele (OR: 1.432, 95% CI: 1.211-1.694, P=2.67×10-5), dominant (OR: 1.466, 95% CI: 1.215-1.769, P=6.33×10- 5), recessive (OR: 0.539, 95% CI: 0.303-0.960, P=0.036), heterozygous (OR: 0.700, 95% CI: 0.577-0.849, P=3.06×10-4), and homozygous (OR: 0.472, 95% CI: 0.265- 0.839, P=0.011) genetic models. Conclusions: LEPR Gln223Arg gene polymorphism was associated with an increased risk of T2DM in the Chinese population. Therefore, Chinese carriers of the G allele of LEPR Gln223Arg gene polymorphism may be more susceptible to T2DM than the general population.




Li, Y. Y., Wang, H., Yang, X. X., Wu, J. J., Geng, H. Y., Kim, H. J., … Wang, L. S. (2017). LEPR gene Gln223Arg polymorphism and type 2 diabetes mellitus: A meta-analysis of 3,367 subjects. Oncotarget, 8(37), 61927–61934. https://doi.org/10.18632/oncotarget.18720

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