IAPP/amylin gene transcriptional control region: evidence for negative regulation

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Aberrant expression of the islet amyloid polypeptide (IAPP) gene might be involved in the pathogenesis of nun-insulin-dependent diabetes mellitus (NIDDM). Here, we report that IAPP promoter-luciferase constructs revealed tissue-specific activity. This activity was not mediated by cAMP. Sequential 5' deletions of the IAPP promoter caused a progressive derepression of the IAPP gene promoter in IAPP-producing cells. Comparison of the nucleotide sequence of the IAPP promoter with that of the insulin promoter (both active in pancreatic β-cells) reveals two sequence elements of putative importance: an insulin enhancer-like sequence and an element which corresponds to a protected domain in rat insulin I gene promoter footprint experiments. © 1990.




Mosselman, S., Höppener, J. W. M., de Wit, L., Soeller, W., Lips, C. J. M., & Jansz, H. S. (1990). IAPP/amylin gene transcriptional control region: evidence for negative regulation. FEBS Letters, 271(1–2), 33–36. https://doi.org/10.1016/0014-5793(90)80365-P

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