The effect of stereochemistry on sodium ion complexation in nucleoside-metallacarborane conjugates

Abstract

Conjugates of purine and pyrimidine nucleosides: Thymidine and 2 ′ -deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1:1 stoichiometry was proved by ESI MS spectroscopy and23 Na NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkalimetals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications. Copyright © 2010 Agnieszka B. Olejniczak et al.