Buprenorphine is relatively resistant to reversal by naloxone. We tested the effect of various doses and infusion schemes of naloxone on buprenorphineinduced respiratory depression and compared the data with naloxone-reversal of morphine and alfentanil-induced respiratory depression. Both morphine and alfentanil were easily reversed by low doses of naloxone (0.4 mg). Increasing doses of naloxone caused a bell-shaped reversal curve of buprenorphine with maximal reversal at naloxone doses between 2 and 4 mg. However, reversal was short-lived. The bell-shaped reversal curve may be related to the existence of two μ-opioid receptor subtypes, one mediating the agonist effects of opioids at low dose, the other mediating antagonistic effects at high dose. © 2008 Springer Science+Business Media, LLC.
CITATION STYLE
Sarton, E., Teppema, L., & Dahan, A. (2008). Naloxone reversal of opioid-induced respiratory depression with special emphasis on the partial agonist/antagonist buprenorphine. In Advances in Experimental Medicine and Biology (Vol. 605, pp. 486–491). https://doi.org/10.1007/978-0-387-73693-8_85
Mendeley helps you to discover research relevant for your work.