Electrolytic extracellular phantom to study the low-frequency conductivity of cervical neoplasia

Abstract

In this work we performed an electrolytic phantom based on an extracellular media containing different ionic species simulating extracellular electrical conductivities to study different cervical neoplastic stage which have been reported in the literature (1). An aqueous electrolytic solution composed by sodium, calcium and potassium salts was selected to emulate the ionic species in the extracellular media. The extracellular conductivities of normal and neoplastic tissues were simulated using different dilutions of extracellular model with the same relation between concentrations of each ionic species. The conductivities values ranged from 1190 μS/cm to 4386 μS/cm. At low frequencies, abnormal tissue shown a conductivity greater than normal tissue. Our results suggests that the extracellular medium of an abnormal tissue can be modeled using an electrolytic solution with a higher concentration of ionic species more than in a normal tissue.