A variety of transcription factors has been shown to regulate lineage commitment in the mammary gland and to be associated with different molecular subtypes of breast cancer. E74-like factor 5 (Elf5) has now been identified as a marker of oestrogen receptor status, and high expression correlates with more aggressive basal cancers and resistance to anti-oestrogens. Manipulation of Elf5 transcript levels perturbs the molecular profiles of luminal and basal subtypes, highlighting the possibility that targeting Elf5 could provide a new approach for the treatment of basal cancers. © 2013 BioMed Central Ltd.
CITATION STYLE
Frend, H. T., & Watson, C. J. (2013, March 27). Elf5 - breast cancer’s little helper. Breast Cancer Research. https://doi.org/10.1186/bcr3397
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