Toxicology evaluation and properties of a new biodegradable computer made medical biomaterial

Abstract

Background: Poly (propylene carbonate) (PPC) synthesized from carbon dioxide and propylene oxide has attracted considerable research attention recently. To explore the potential application of these new polymers for bone repair, it is necessary to use other biodegradable polymers to enhance the properties of PPC. Poly (3-hydroxybutyrate) was used in this study to modify the mechanical properties and biocompatibility of PPC. Methods: Poly (propylene carbonate) (PPC) was melt-mixed with 30 % poly (3-hydroxybutyrate) to enhance its physical properties, while maintaining the inherently high structural integrity and ductility. The mechanical strength, porosity, morphologies and biocompatibility of porous modified-PPC (PM-PPC) were fully investigated using tensile tester, hammering method, scanning electron microscopy, cytotoxicity test for its biocompatibility. Results: The PM-PPC was measured by mechanical tests for its compressive strength, elongation module and tensile strength, with the results being 43, 725 and 32 Mpa respectively. The data showed that the mechanical properties of PM-PPC were significantly improved compared with PPC. The mean porosity of PM-PPC was 15%, as determined by hammering method. The biocompatibility test of PM-PPC showed that it has excellent potential for use as a biomedical material. Conclusions: In conclusion, the PM-PPC showed improved mechanical properties, and an acceptable biocompatibility supporting its potential for use in patients. Thus, PM-PPC is a promising candidate for use as a novel medical material. © Springer Science+Business Media Dordrecht 2014.