Antitumor activities have been described in selol, a hydrophobic mixture of molecules containing selenium in their structure, and also in maghemite magnetic nanoparticles (MNPs). Both selol and MNPs were co-encapsulated within poly(lactic-co-glycolic acid) (PLGA) nanocapsules for therapeutic purposes. The PLGA-nanocapsules loaded with MNPs and selol were labeled MSE-NC and characterized by transmission and scanning electron microscopy, electrophoretic mobility, photon correlation spectroscopy, presenting a monodisperse profile, and positive charge. The antitumor effect of MSE-NC was evaluated using normal (MCF-10A) and neoplastic (4T1 and MCF-7) breast cell lines. Nanocapsules containing only MNPs or selol were used as control. MTT assay showed that the cytotoxicity induced by MSE-NC was dose and time dependent. Normal cells were less affected than tumor cells. Cell death occurred mainly by apoptosis. Further exposure of MSE-NC treated neoplastic breast cells to an alternating magnetic field increased the antitumor effect of MSE-NC. It was concluded that selol-loaded magnetic PLGA-nanocapsules (MSE-NC) represent an effective magnetic material platform to promote magnetohyperthermia and thus a potential system for antitumor therapy. © 2012 Cárdenas et al, publisher and licensee Dove Medical Press Ltd.
CITATION STYLE
Estevanato, L. L. C., Da Silva, J. R., Falqueiro, A. M., Mosiniewicz-Szablewska, E., Suchocki, P., Tedesco, A. C., … Lacava, Z. G. M. (2012). Co-nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: In vitro evaluation of cytotoxicity and magnetohyperthermia efficacy. International Journal of Nanomedicine, 7, 5287–5299. https://doi.org/10.2147/IJN.S35279
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