Interleukin-6: An emerging regulator of pathological pain

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Abstract

Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and its receptor in the spinal cord and dorsal root ganglia. Additionally, the administration of interleukin-6 could cause mechanical allodynia and thermal hyperalgesia, and an intrathecal injection of anti-interleukin-6 neutralizing antibody alleviated these pain-related behaviors. These studies indicated a pivotal role of interleukin-6 in pathological pain. In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund's adjuvant injection, and carrageenan injection. Understanding and regulating interleukin-6 could be an interesting lead to novel therapeutic strategies for pathological pain.

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CITATION STYLE

APA

Zhou, Y. Q., Liu, Z., Liu, Z. H., Chen, S. P., Li, M., Shahveranov, A., … Tian, Y. K. (2016, June 7). Interleukin-6: An emerging regulator of pathological pain. Journal of Neuroinflammation. BioMed Central Ltd. https://doi.org/10.1186/s12974-016-0607-6

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