Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities

Abstract

Saponins are plant-derived non-ionic surfactants and widely applied in many products, such as cosmetics, cleansers, medicines, vaccine, as additives by therapeutic properties and chemical characteristics theirs. These substances are of growing interest for drug research as they’re active constituents of several folk medicines, in addition to comprising an important class of medicinal chemistry. Triterpenoid saponins are secondary metabolites, these’re largely distributed in plant species and they’re characterized as one of the active principles of these. These saponins have potent anti-viral, adjuvant, hemolytic, cytotoxic and anti-angiogenic activities that are relationship with the presence of characteristics chemical moiety. In this work was summarized the studies found in the scientific literature on the therapeutic properties of triterpenoid saponins, as well as commercial applicability theirs. Recent works have suggested some triterpenoid saponins like candidates for treatment of patients with COVID-19.