CLL: Promiscuity leads to risks

Abstract

In this issue of Blood, Seiler and colleagues confirm that phage display is a feasible technology to identify specific ligands of antigen receptors expressed by CLL B cells. Importantly, they demonstrate that somatic hypermutation influences the range of specificities of the clonotypic BCRs. Furthermore, they raise the intriguing possibility that mimetic ligands to CLL BCRs might be of therapeutic use.