Accelerated nodulosis during methotrexate therapy for refractory rheumatoid arthritis: A case report

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Abstract

Accelerated nodulosis (AN) is a potential complication of methotrexate (MTX) therapy for rheumatoid arthritis (RA). We report on a 62-year old man affected by seropositive RA who developed AN after five months of MTX treatment. MTX-dose reduction was followed by rapid regression of the skin nodules. The Authors describe the typical features of AN and discuss on the pathogenetic mechanisms.

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Filosa, G., Salaffi, F., & Bugatti, L. (1999). Accelerated nodulosis during methotrexate therapy for refractory rheumatoid arthritis: A case report. In Advances in Experimental Medicine and Biology (Vol. 455, pp. 521–524). Kluwer Academic/Plenum Publishers. https://doi.org/10.1007/978-1-4615-4857-7_77

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