Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: A very strong risk factor for adenovirus DNAemia in pediatric patients

Abstract

Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation. © 2009 by the Infectious Diseases Society of America.