Stability crossing boundaries of delay systems modeling immune dynamics in leukemia

Abstract

This paper focuses on the characterization of delay effects on the asymptotic stability of some continuous-time delay systems encountered in modeling the post-transplantation dynamics of the immune response to chronic myelogenous leukemia. Such models include multiple delays in some large range, from one minute to several days. The main objective of the paper is to study the stability of the crossing boundaries of the corresponding linearized models in the delay-parameter space by taking into account the interactions between small and large delays. Weak and strong cell interactions are discussed and analytic characterizations are proposed. An illustrative example together with related discussions completes the presentation.