The Molecular Pathology of Serous Endometrial Cancer

Abstract

Serous endometrial cancer is a particularly aggressive form of uterine cancer that is associated with a poor prognosis. In the era of precision medicine, defining the molecular alterations that drive tumor development can uncover druggable targets for which molecularly based therapies already exist as well as provide a starting point to develop novel targeted therapies and companion diagnostics. In this chapter, we review the current state of knowledge regarding the molecular pathology of serous endometrial cancer, and discuss how this knowledge is being utilized in the clinical setting.