The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8-hydroxy-2′-deoxyguanosine

Abstract

Objectives: Recent studies have revealed the relationship of oxidative stress to various medical disorders, such as cancer and ischemic heart disease. Atopic dermatitis (AD) and psoriasis vulgaris (PV) are chronic inflammatory dermatoses, and oxidative stress is presumed to be involved in the development of these diseases as well as their becoming refractory. Methods: In this study, we collected urine samples from 40 AD patients, 25 PV patients, and 39 healthy volunteers (HVs). The level of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in each urine sample was measured and then compared among the groups. We also evaluated the relationship between the AD and PV severity and the urinary 8-OHdG level. Results: We found that the urinary 8-OHdG level was significantly higher in the AD and PV groups than in the HV group. We did not, however, identify an association between the 8-OHdG level and the age, disease duration, or disease severity in the AD or PV groups. Conclusions: Our results demonstrated an association between urinary 8-OHdG and the development of AD and PV, suggesting that both are oxidative stress-related diseases. Treatments or lifestyle improvements focused on anti-oxidation may therefore be vital for preventing these chronic dermatoses from developing and becoming refractory.