A systematic review of the biochemical troubles associated with Trisomy 21 lead to three constatations: 1) There must be an important perturbation of the oxygen metabolism (Excess of S.O.D.I. and of G.P.X.) 2) There is probably a shift in the regulation of non essential amino acids (Comparison with other forms of mental deficiencies) 3) In conformity with a general hypothesis, an abnormality of the monocarbon metabolism could be the consequence of 1) and 2) and could represent the actual cause of mental deficiency.
CITATION STYLE
Lejeune, J. (1981). 20 years later. Human Genetics. Supplement, 2, 91–101. https://doi.org/10.1007/978-3-642-68006-9_8
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