Effects of Long-term Administration of Indigestible Dextrin as Soluble Dietary Fiber on Lipid and Glucose Metabolism.

Abstract

[Abstract] Sugar and fat metabolism of high viscous dietary fibers i.e. guar gum, pectin, etc., have ever been examined in details 1). It has been reported that guar gum or pectin inhibits the intestinal absorption of glucose and lipid markedly, and decrease blood glucose and lipid levels by a long-term administration 2-4). At the same time, those dietary fibers inhibit the absorption of trace metals 5) and medicines 6) , however, it remains a problem to apply to a clinical use. Compared with those, indigestible dextrin that has been recently developed has high solubility and low viscosity as same as polydextrose 5). Additionally, different from guar gum or pectin, indigestible dextrin does not have inhibitive functions of metal or medicine absorption 5) , however, several reports are available on the clinical effects of long-term administration of indigestible dextrin. In this study, we conducted a successive, long-term administration of indigestible dextrin to experimental animals and hyperlipidemic patients with non-insulin-dependent diabetes mellitus (NIDDM), and investigated its clinical effects. Subjects and methods 1. Animal Experiments SD male rats (Nippon Crea, 3-week old, n=13) were used for this experiments. In order to exclude the influence of lipid in feed, especially with cholesterols, the rats were fed for 2 weeks with feed containing no cholesterol 8) (casein: 25%, corn oil: 5%, salt mixture 9) 4%, vitamin mixture 9) : 1%, choline chloride: 0.2%, vitamin E granule: 0.05%, sucrose: 64.75%). The rats were then divided in two groups and conducted the following study.