This report describes a trypsin-resistant laddering protein purified from a type V strain, a serotype of important emerging clinical significance. This protein is present in a majority of type V clinical strains, elicits protective antibody in an animal model, and is cross-reactive with the alpha C protein and R1. The gene encoding this protein has been cloned; preliminary nucleotide sequence analysis reveals significant homology, though not identity, with the alpha C protein gene. These data support the hypothesis that there exists a family of related but distinct GBS surface proteins which may play a role in immunity to GBS infection.
CITATION STYLE
Lachenauer, C. S., & Madoff, L. C. (1997). Cloning and expression in Escherichia coli of a protective surface protein from type V Group B streptococci. In Advances in Experimental Medicine and Biology (Vol. 418, pp. 615–618). Springer New York LLC. https://doi.org/10.1007/978-1-4899-1825-3_143
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