The Open Field Test for Measuring Locomotor Activity and Anxiety-Like Behavior

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Abstract

The open field test is used in studies of the neurobiological basis of anxiety and screening for novel drug targets and anxiolytic compounds. This test uses a camera to measure movement of the test animal in the peripheral and central zones of a 42 × 42 × 42 cm polyvinyl chloride box. This chapter describes a protocol for carrying out the open-field test for assessment of locomotion and anxiety-like behavior in mice.

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Kraeuter, A. K., Guest, P. C., & Sarnyai, Z. (2019). The Open Field Test for Measuring Locomotor Activity and Anxiety-Like Behavior. In Methods in Molecular Biology (Vol. 1916, pp. 99–103). Humana Press Inc. https://doi.org/10.1007/978-1-4939-8994-2_9

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