Is It All About Endothelial Dysfunction and Thrombosis Formation? The Secret of COVID-19

16Citations
Citations of this article
42Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The world is in a hard battle against COVID-19. Endothelial cells are among the most critical targets of SARS-CoV-2. Dysfunction of endothelium leads to vascular injury following by coagulopathies and thrombotic conditions in the vital organs increasing the risk of life-threatening events. Growing evidences revealed that endothelial dysfunction and consequent thrombotic conditions are associated with the severity of outcomes. It is not yet fully clear that these devastating sequels originate directly from the virus or a side effect of virus-induced cytokine storm. Due to endothelial dysfunction, plasma levels of some biomarkers are changed and relevant clinical manifestations appear as well. Stabilization of endothelial integrity and supporting its function are among the promising therapeutic strategies. Other than respiratory, COVID-19 could be called a systemic vascular disease and this aspect should be scrutinized in more detail in order to reduce related mortality. In the present investigation, the effects of COVID-19 on endothelial function and thrombosis formation are discussed. In this regard, critical players, laboratory findings, clinical manifestation, and suggestive therapies are presented.

Cite

CITATION STYLE

APA

Elyaspour, Z., Zibaeenezhad, M. J., Razmkhah, M., & Razeghian-Jahromi, I. (2021). Is It All About Endothelial Dysfunction and Thrombosis Formation? The Secret of COVID-19. Clinical and Applied Thrombosis/Hemostasis. SAGE Publications Inc. https://doi.org/10.1177/10760296211042940

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free