Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation

  • Sundblad V
  • Morosi L
  • Geffner J
  • et al.
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Abstract

Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation. Likewise, this lectin controls T cell and B cell compartments by modulating receptor clustering and signaling, thus serving as a negative-regulatory checkpoint that reprograms cellular activation, differentiation, and survival. In this review, we discuss the central role of Gal-1 in regulatory programs operating during acute inflammation, autoimmune diseases, allergic inflammation, pregnancy, cancer, and infection. Therapeutic strategies aimed at targeting Gal-1–glycan interactions will contribute to overcome cancer immunosuppression and reinforce antimicrobial immunity, whereas stimulation of Gal-1–driven immunoregulatory circuits will help to mitigate exuberant inflammation.

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APA

Sundblad, V., Morosi, L. G., Geffner, J. R., & Rabinovich, G. A. (2017). Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation. The Journal of Immunology, 199(11), 3721–3730. https://doi.org/10.4049/jimmunol.1701172

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