Infección por papiloma virus humano y carcinoma escamocelular bucal, diversas técnicas moleculares para detectar su presencia

Abstract

Oral cancer (BC) is an aggressive malignancy that includes 4 to 5% of all tumors with a high mortality rate, the vast majority are squamous cell carcinomas (90%). Among the factors risk associated with CB are described smoking, genetic predisposition, alcohol and recently mentioned some virus papilloma virus (HPV) among others. The aim of this paper is to review literature reports that account for the relationship between CB and HPV, specifically describing the molecular behavior of HPV high risk, the genome map of the virus and its possible relationship with CB. The Scientific evidence shows that between 15 to 30% of CB are related to HPV, specifically the subtype 16 considered high risk oncogenic and that individuals with oral HPV presence are twice increased risk of developing a CB who is not exposed to the virus.