Adalimumab Treatment of life-threatening uberculosis

Abstract

Most guidelines call for the discontinuation of treatment with tumor necrosis factor blockers in patients who develop tuberculosis. We report a case of life-threatening tuberculosis paradoxical reaction involving the lungs caused by withdrawal of the anti-tumor necrosis factor antibody adali- mumab. Clinical improvement occurred only after resumption of adalimumab treatment. © 2009 by the Infectious Diseases Society of America.