Synthesis and antimicrobial evaluation of thiadiazole derivatives

Abstract

A new series of thiadiazole derivatives were synthesized and screened for their antimicrobial activity. All the newly synthesized compounds were screened for their antibacterial activity against Gram positive species Bacillus subtilis, Staphylococcus aureus and Gram negative species Pseudomonas aeruginosa, E. coli and Candida albicans, A. niger species were used as organism for antifungal activity. Compounds 5c and 5e shows potent activity against the test bacteria and fungi, and emerged as potential molecules for further development. Compounds having substituted phenyl ring were found more biological active and compounds having phenyl ring substituted with electron withdrawing groups gives highest antimicrobial activity.