Application of liquid chromatography-mass spectrometry in the research of Alzheimer's disease

Abstract

Liquid chromatography-mass spectrometry (LC-MS) combining with both highly efficient separation and detection is widely applied to chemistry, medicine, pharmacy biochemistry etc. Particularly, the application of LC-MS to clinic chemistry opened a new chapter for diagnosis technologies. Alzheimer' s disease (AD), also called as senile dementia, is the fourth leading cause of death in modern society. With the rapid aging of population, the prevention and treatment of AD need to be strengthened. In this review, we briefly introduce the new LC-MS developments and discuss the applications of LC-MS techniques in AD research in the last three years.