Hydroxy-3,4-dehydro-apo-8′-lycopene and methyl hydroxy-3,4-dehydro- apo-8′-lycopenoate, novel C 30 carotenoids produced by a mutant of marine bacterium Halobacillus halophilus

Abstract

We performed the chemical mutagenesis of Halobacillus halophilus (the producer of a C 30 carotenoid, methyl glucosyl-3,4-dehydro-apo-8′- lycopenoate) to isolate novel carotenoids that are biosynthetic intermediates of methyl glucosyl-3,4-dehydro-apo-8′-lycopenoate. As a result, we isolated two novel C 30 carotenoids, hydroxy-3,4-dehydro-apo-8′-lycopene and methyl hydroxy-3,4-dehydro-apo-8′-lycopenoate, which were biosynthesized through a novel 8′-apo C 30 pathway. These carotenoids showed antioxidative activity in the 1 O 2 suppression model. © 2010 Japan Antibiotics Research Association All rights reserved.