Clustering of Klebsiella Strains Based on Variability in Sequencing Data

Abstract

Genotyping is a method necessary to distinguish between strains of bacteria. Using whole sequences for analysis is a computational demanding and time-consuming approach. We establish a workflow to convert sequences to a numerical signal representing the variability of sequences. After segmentation and using only parts of the signals, they have still enough information to form a topologically according to the clustering structure.