Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which represent a predominant cell type in tumor microenvironment, play a pivotal role in determining the ultimate fate of tumor cells. This review recapitulates the pleiotropic roles of fibroblasts which are divided into normal, senescent, cancer-associated fibroblasts (CAFs) and circulation CAFs in tumor dormancy, relapse, metastasis and resistance to therapy to help the treatment of cancer metastasis.
CITATION STYLE
Dai, L., Li, M., Zhang, W. long, Tang, Y. J., Tang, Y. ling, & Liang, X. hua. (2021, December 1). Fibroblasts in cancer dormancy: foe or friend? Cancer Cell International. BioMed Central Ltd. https://doi.org/10.1186/s12935-021-01883-2
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