Asymmetric Hydrogenation of Imines

Abstract

Homogeneous catalytic asymmetric hydrogenation has evolved into a significantly useful methodology for the preparation of enantiopure compounds. Significant advances in asymmetric hydrogenation of imines have enabled a straightforward and powerful approach to various chiral amines. An overview of the many variants of the chiral transition metal catalysts, illustrations of synthetic applications, and discussions of emerging and future strategies from a mechanistic perspective are presented.