Middle interhemispheric variant of holoprosencephaly

Abstract

A preterm baby girl born at 33 weeks’ gestation to a mother with maternal diabetes and a history of perinatal cocaine-use was diagnosed prenatally with midline interhemispheric variant (MIHV) of holoprosencephaly via ultrasonography and fetal MRI at 19 weeks’ gestation. At birth, the patient exhibited a prominent forehead, hypotelorism, a short upturned nose, and short palpebral fissures. While she exhibited difficulty feeding, the remainder of her neurological examination was normal.