The role of mortalin in iron homeostasis

Abstract

The role of chaperones in prokaryotic and eukaryotic iron-sulfur cluster assembly pathways is discussed in the context of the complex sequence of events that are involved in [2Fe-2S] cluster biogenesis. Building from a background description of the functions of the component proteins and the various stages of cluster assembly and transfer to target proteins, similarities and differences in chaperone functions are presented with a particular focus on the unique characteristics of mortalin, relative to other chaperones.