Immune Response of Cattle to Different Serotype Antigens in Monovalent and Trivalent Foot-and-Mouth Disease Vaccines

Abstract

Inactivated foot-and-mouth disease vaccines, prepared from monovalent and trivalent 140 S antigens in which the virus mass was balanced according to complement-fixing titers, were compared in cattle. The vaccine containing type C virus produced significantly higher neutralizing antibody levels and disease resistance against challenge with homologous virus than did those containing types A and O. No significant differences occurred in antibody levels or immunity between monovalent and trivalent vaccines, indicating the absence of a foot-and-mouth disease immunizing antigen common to all three types.