Serum 25(OH) vitamin d level is associated with treatment outcome of whole-body vibration (WBV) for osteopenia in girls with adolescent idiopathic scoliosis (AIS)

Abstract

Objectives AIS was associated with low bone mass which, apart from being an important health issue that could persist into adulthood, was also a significant prognostic factor for curve progression in AIS. We have performed a ran-domized controlled trial on WBV and reported its effect on increasing femoral neck areal bone mineral density (aBMD) mainly at the dominant leg but less obviously at the non-dominant side. The objective of this study was to evaluate the role of Vit-D in affecting the ana-bolic bone effect of WBV. Material and methods This was a study nested within a randomized controlled trial with enrolment of 122 AIS girls (15-25 years old) with BMD Z-scores 40nmol/L revealed not only the positive effects of WBV were greater at both sides, treatment effects were explicitly also noted at the non-dominant leg. In addition, the positive correlation between serum 25(OH)Vit-D and percentage increase in femoral neck aBMD that was not present in the Control group was explicitly detectable in the Treatment group at the non-dominant leg(p=0.004). Conclusions The results strongly suggested the treatment effect of WBV could be enhanced through its synergistic factor interaction with Vit-D. The study carried significant clinical implication in that Vit-D insufficiency could affect negatively the treatment outcome of WBV for low bone mass in girls with AIS.