Mucoadhesive polymers and ocular lubricants

Abstract

Dry Eye Disease (DED) is defined as a multifactorial condition that results in discomfort, visual disturbance, tear film instability and damage to the ocular surface. It is characterized by the increased osmolarity of the tear film and inflammation of the ocular surface. Tear film stability is maintained by the coordinated functions of the outer lipid monolayer with its critical composition and the contents of aqueous interface. This chapter discusses the structure and function attributing to tear film integrity, mucoadhesive polymers used in tear substitutes/lubricants, tear secretagogues agents, anti-inflammatory immunosuppressants, and use of autologous serum, umbilical cord serum for the management of dry eye.