Crushed Puffed Rice-HPMC-chitosan based single-unit Hydro-dynamically Balanced System for the sustained stomach specific delivery of metoprolol succinate

Abstract

Purpose: Developed and evaluated a Hydrodynamically Balanced System (HBS) capsule system using natural and novel biodegradable polymer used as Crushed Puffed Rice (CPR) alone and in combination with auxiliary polymers (High Molecular Weight Chitosan; HMWCH and Hydroxypropyl methylcellulose; HPMC K15) for stomach specific delivery. Method: A total of nine formulations was prepared by manual shaking method and filled in colorless hard capsule shell size 1. The prepared capsule was evaluated for parameters such as drug content, in vitro buoyancy and drug release in 0.1M HCl, drug delivery kinetics. Results: Average floating time for the formulation is 08 hours. CPR is used as a buoyancy imparting agent due to its floating behavior; it floats in 0.1 M HCl (pH 1.2) and remained unwetted for the time period of 05 hours. CPR, HPMC K15, and HMWCH have a significant effect (p < 0.05) on MS retarding. Formulation D1-D9 follows zero order model and Fickian diffusion which was confirmed by R2 value and Akaike Information Criteria (AIC). Conclusion: The data obtained from the study suggests that CPR in combination with HMWCH or HPMC K15 or HPMC K15 + HMWCH has sufficient potential to be used as a carrier for stomach specific drug delivery.