Effect of antibiotic growth promoters on anti-oxidative and anti-inflammatory activities in broiler chickens

Abstract

The current study was conducted to evaluate the effects of sub-therapeutic antibiotics (avilamycin and flavophospholipol) in animal feed on anti-oxidative and anti-inflammatory properties in broilers to understand the mechanisms of AGPs. Four hundred and fifty six 1-day-old broilers (ROSS 308) were divided into 3 groups with 4 replications. Three experimental diets composed of a corn-soybean meal based diet supplemented with 0, 10 mg/kg avilamycin and 5 mg/kg flavophospholipol were randomly provided to the broilers for 42 days, respectively. Results showed that the AGPs significantly decreased TBA-MDA adduct in serum as well as villi tissue of the broilers, especially flavophospholipol. However, flavophospholipol and avilamycin significantly increased IFN-γ and TNF-α concentration in the serum of broilers. TGF-β was not affected by the AGPs supplementation. These results indicated that the anti-oxidative and immune modulatory properties of AGPs could be an indirect mechanism to promote animal health and production.