NO way! Nasal nitric oxide measurement in infants

Abstract

MARTHIN et al. [27] performed 224 nNO measurements in 44 healthy infants. They reported median (interquartile range) concentrations of 15.0 (9.6 to 22.8) nL min-1 in newborns, increasing to 93.4 (67.0 to 128.4) nL min-1 at the age of 24 months. Respiratory tract infections temporarily suppressed nNO by 79% [27]. The success rate of acceptable nNO-sampling was 223/224 (99.6%). With further validation and standardisation, nNO may prove an important diagnostic tool for infants with PCD. This would allow earlier initiation of appropriate management strategies, thereby reducing the risk of early lung damage and respiratory decline.