The induction of pro- and anti-inflammatory cytokines and chemokines was studied in the lungs of cotton rats after primary or secondary infection with respiratory syncytial virus (RSV). Increases in messenger RNA (mRNA) levels of all genes analyzed were observed during the course of primary infection. In general, mRNA expression peaked between postinfection days 1 and 4 and returned to near-normal levels by day 10. During secondary infection, the expression of some genes (i.e., interferon [IFN]-γ and interleukin [IL]-10) began earlier, some (i.e., IL-1β and macrophage inflammatory protein-1β) began later, and some (i.e., IL-1β, IL-10, growth-regulated protein, and tumor necrosis factor-α) showed prolonged expression, whereas 2 genes (i.e., IFN-α and IL-6) were not expressed. This study presents evidence of different kinetics of expression of inflammatory mediators during primary and secondary infection that likely coincide with innate and adaptive immune response and complement previous observations that emphasize the role of inflammation in the pathogenesis of RSV disease.
CITATION STYLE
Blanco, J. C. G., Richardson, J. Y., Darnell, M. E. R., Rowzee, A., Pletneva, L., Porter, D. D., & Prince, G. A. (2002). Cytokine and chemokine gene expression after primary and secondary respiratory syncytial virus infection in cotton rats. Journal of Infectious Diseases, 185(12), 1780–1785. https://doi.org/10.1086/340823
Mendeley helps you to discover research relevant for your work.