Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: Significant bone health issues in those not taking HRT

Abstract

Background:Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision to use HRT to cover the period of oestrogen deprivation up to 50 years of age is difficult because of balancing the considerations of breast cancer risk, bone and cardiovascular health.Methods:We reviewed by questionnaire 289 women after BRRSPO aged 48 years because of high ovarian cancer risk; 212 (73%) of women responded.Results:Previous HRT users (n67) had significantly worse endocrine symptom scores than 67 current users (P0.006). A total of 123 (58%) of women had 24 months of oestrogen deprivation 50 years with 78 (37%) never taking HRT. Bone density (DXA) evaluations were available on 119 (56%) women: bone loss with a T score of 1.0 was present in 5 out of 31 (16%) women with no period of oestrogen deprivation 50 years compared with 37 out of 78 (47%) of those with 24 months of oestrogen deprivation (P0.03).Interpretation:Women undergoing BRRSPO 50 years should be counselled concerning the risks/benefits of HRT, taking into consideration the benefits on symptoms, bone health and cardiovascular health, and that the risks of breast cancer from oestrogen-only HRT appear to be relatively small. © 2011 Cancer Research UK All rights reserved.