The ketogenic diet, known as a low-carbohydrate, high-protein, and high-fat diet, drastically restrains the major source of energy for the body, forcing it to burn all excess fat through a process called ketosis—the breaking down of fat into ketone bodies. First suggested as a medical treatment for children suffering from epilepsy, this diet has gained increased popularity as a rapid weight loss strategy. Over the past few years, there have been numerous studies suggesting that the ketogenic diet may provide therapeutic effects for several psychiatric conditions such as mood- and anxiety-related disorders. However, despite significant progress in research, the mechanisms underlying its therapeutic effects remain largely unexplored and are yet to be fully elucidated. This chapter provides an in-depth overview of preclinical and clinical evidence supporting the use of a ketogenic diet in the management of mood and anxiety disorders and discusses its relationship with inflammatory processes and potential mechanisms of actions for its therapeutic effects.
CITATION STYLE
El Karkafi, R., Gebara, T., Salem, M., Kamel, J., El Khoury, G., Zalal, M., & Fakhoury, M. (2023). Ketogenic Diet and Inflammation: Implications for Mood and Anxiety Disorders. In Advances in Experimental Medicine and Biology (Vol. 1411, pp. 537–554). Springer. https://doi.org/10.1007/978-981-19-7376-5_23
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