Time‐ and Dose‐dependent Induction of Invasive Urinary Bladder Cancers by N‐Ethyl‐N‐(4‐hydroxybutyl)nitrosamine in B6C3F1 Mice

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Abstract

A sequential investigation of N‐ethyl‐N‐(4‐hydroxybutyl)nitrosamine (EHBN) bladder carcino‐genesis was performed in male B6C3F1mice maintained ad libitum on tap water containing 0.025% EHBN for 4, 12, 20, 28 and 36 weeks. A total of 81 invasive tumors, comprising 55 smiamous cell carcinomas (SCCs) (68%), 25 transitional cell carcinomas (TCCs) (31%) and 1 adenocarcinoma (1%) were found. Of these, 23 (22 SCCs and 1 TCC) demonstrated invasion to the prostate, 3 metastasized to the lung, and 2 spread by peritoneal seeding. The anaplastic grade and extent of invasion of the SCCs significantly exceeded those of the TCCs. The results suggested a histogenetic pathway from simple dysplasia through papillary or nodular dysplasia and/or carcinoma in situ to eventual development of invasive carcinomas Copyright © 1991, Wiley Blackwell. All rights reserved

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Tamano, S., Hagiwara, A., Suzuki, E., Okada, M., Shirai, T., & Fukushima, S. (1991). Time‐ and Dose‐dependent Induction of Invasive Urinary Bladder Cancers by N‐Ethyl‐N‐(4‐hydroxybutyl)nitrosamine in B6C3F1 Mice. Japanese Journal of Cancer Research, 82(6), 650–656. https://doi.org/10.1111/j.1349-7006.1991.tb01900.x

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