Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro

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Abstract

Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.

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Manischewitz, J. F., Quinnan, G. V., Lane, H. C., & Wittek, A. E. (1990). Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro. Antimicrobial Agents and Chemotherapy, 34(2), 373–375. https://doi.org/10.1128/AAC.34.2.373

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