Molecular Mechanism Underlying Role of the XBP1s in Cardiovascular Diseases

4Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Spliced X-box binding protein-1 (XBP1s) is a protein that belongs to the cAMP-response element-binding (CREB)/activating transcription factor (ATF) b-ZIP family with a basic-region leucine zipper (bZIP). There is mounting evidence to suggest that XBP1s performs a critical function in a range of different cardiovascular diseases (CVDs), indicating that it is necessary to gain a comprehensive knowledge of the processes involved in XBP1s in various disorders to make progress in research and clinical therapy. In this research, we provide a summary of the functions that XBP1s performs in the onset and advancement of CVDs such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. Furthermore, we discuss XBP1s as a novel therapeutic target for CVDs.

Cite

CITATION STYLE

APA

Liu, S., Ding, H., Li, Y., & Zhang, X. (2022, December 1). Molecular Mechanism Underlying Role of the XBP1s in Cardiovascular Diseases. Journal of Cardiovascular Development and Disease. MDPI. https://doi.org/10.3390/jcdd9120459

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free