Spliced X-box binding protein-1 (XBP1s) is a protein that belongs to the cAMP-response element-binding (CREB)/activating transcription factor (ATF) b-ZIP family with a basic-region leucine zipper (bZIP). There is mounting evidence to suggest that XBP1s performs a critical function in a range of different cardiovascular diseases (CVDs), indicating that it is necessary to gain a comprehensive knowledge of the processes involved in XBP1s in various disorders to make progress in research and clinical therapy. In this research, we provide a summary of the functions that XBP1s performs in the onset and advancement of CVDs such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. Furthermore, we discuss XBP1s as a novel therapeutic target for CVDs.
CITATION STYLE
Liu, S., Ding, H., Li, Y., & Zhang, X. (2022, December 1). Molecular Mechanism Underlying Role of the XBP1s in Cardiovascular Diseases. Journal of Cardiovascular Development and Disease. MDPI. https://doi.org/10.3390/jcdd9120459
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