Leucocyte ascorbic acid levels after acute myocardial infarction

Abstract

Leucocyte ascorbic acid was measured in 31 patients who had sustained an acute myocardial infarction. Nine of the patients were seen within 6 hours of the infarction and 22 patients within 12 hours. It was found that there was a significant fall in the leucocyte ascorbic acid to scorbutic levels within 12 hours of the infarction in each casey and this occurred when the white blood cell count was at its maximum. The fall also coincided with the peak plasma Cortisol level. The level remained less than normal for the next two weeks and the reduction in leucocyte ascorbic acid at two weeks was related to the size of the myocardial infarction as reflected by the serum aspartate aminotransferase level. It is suggested that the fall in leucocyte ascorbic acid is due to the migration of ascorbic acid laden leucocytes to the site of the infarction and the dilution of the white cell pool by cells which have not yet taken up their ascorbic acid from the plasma. This is in keeping with the finding of higher heart muscle concentrations of ascorbic acid in patients dying a coronary death as compared with patients dying a non-coronary death. These changes appear to be under the influence of the adrenal glands and are a response to traumatic stress.